Epithelial senescence
WebAug 10, 2024 · A closer examination revealed an enrichment of a TP53-mediated cellular senescence signature. This signature may arise from extensive stretching of AT2 cells … WebSenescence has attracted attention because of its potential use in anticancer therapy as it plays a tumor-suppressive role. It also promotes tumorigeneses and therapeutic resistance. ... Oxidative stress induced senescence and epithelial-to-mesenchymal transition (EMT) in amnionic epithelial cells (AEC) via p38MAPK activation . Since ...
Epithelial senescence
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WebMar 1, 2015 · Cellular senescence is a state of irreversible growth arrest in the G 1 phase of the cell cycle. 1, 2 Telomere shortening, double-stranded DNA damage, inflammation, and other forms of cell stress all function as stimuli for cell senescence. WebJan 27, 2024 · We previously reported that biliary epithelial cell senescence (cell-cycle arrest and hypersecretion of profibrotic molecules) is an important phenotype in primary sclerosing cholangitis. Herein, we demonstrate that reducing the number of senescent cholangiocytes leads to a reduction in the expression of inflammatory, fibrotic, and …
WebOct 15, 2006 · In this study we investigated whether the senescence of alveolar epithelial and endothelial cells is accelerated in emphysematous lungs. Methods: Samples of lung tissue were obtained from patients with emphysema, asymptomatic smokers, and asymptomatic nonsmokers. WebJul 13, 2024 · Two-step senescence of human keratinocytes and mammary epithelial cells. a Schematic representation of the in vitro growth curves.b Schematic representation of …
WebFeb 14, 2024 · Senescence of tubular epithelial cells promotes EMT and leads to the SASP, which increases inflammation and pathological accumulation of extracellular matrix, ultimately resulting in fibrosis and the development of CKD. WebDDR has been the subject of further research lately, including studies on its function in renal tubular epithelial cells. Cellular communication factor 2 (CCN2, also known as CTGF) is a significant factor in the development of CKD and was found to exacerbate DNA damage and the ensuing DDR-cellular senescence-fibrosis sequence after renal IRI.
WebMar 24, 2024 · Alveolar epithelial type 2 cell (AEC2) senescence is generally considered to be a driver of IPF (Parimon et al., 2024). Cellular senescence refers to permanent cell cycle arrest in response to endogenous and exogenous stimuli, such as oncogene activation, mitochondrial dysfunction, and oxidative stress ( Herranz and Gil, 2024 ).
WebJan 10, 2024 · Age-related cell loss underpins many senescence-associated diseases. Apoptosis of lens epithelial cells (LECs) is the important cellular basis of senile cataract resulted from prolonged... roswell castleWebJan 10, 2024 · The senescence of lens epithelial cells (LECs) is a major factor leading to age-related cataract (ARC). ARC results in visual impairment and severe vision loss in … story of the bataviaWebOct 2, 2001 · Here, we show that senescent human fibroblasts promote the proliferation and tumorigenesis of mutant epithelial cells. Our data suggest that cellular senescence is … roswell car washWebIndeed, IPF is characterised by increased epithelial [ 20 – 22] and mesenchymal/fibroblast [ 19] senescence. L ehmann et al. [ 18] focused on epithelial senescence in IPF, confirming that lung epithelial cells display senescence markers such as SAβG, P21, P16 INK4a and DNA damage response markers in IPF patients. story of the babushka ladyWebThus, the aim of this study was to evaluate apoptosis, oxidative stress, autophagy and microRNA (miR) expression in multipotent intestinal epithelial stem cells (IECs) and pancreatic islets (PIs) isolated post mortem form healthy and EMS diagnosed horses. Our group was the first to describe how EMS affects IEC and PI aging and senescence. story of the bansheeWebMar 18, 2024 · This process, which sees epithelial cells lining surfaces of the body lose their identity and become mesenchymal, is common in development and cancer. Further experiments revealed that cells change how they use and generate energy as they progress towards replicative senescence. roswell cbocWebThe epithelium of embryos lacking macrophage Nrf2 also exhibited elevated levels of the Drosophila p21/p27 homolog (Dacapo; Fig. 5, O and P), suggesting that persistent ROS-induced epithelial damage might trigger the acquisition of cellular features typically associated with early senescence, despite non-immune tissues retaining normal levels ... story of the arch of the covenant