WebMar 1, 2009 · In around 40% of the patients a peculiar granulocytic infiltration of the epithelial duct has been reported that was termed granulocytic epithelial lesion (GEL).22 Two main subtypes with differing clinicopathologic features can be distinguished: one called lymphoplasmacytic sclerosing pancreatitis,21 lobulocentric,36 or GEL-negative ... WebJan 27, 2016 · Sclerosing cholangitis with granulocytic epithelial lesion (GEL) GEL is a pathognomonic histological finding of type 2 AIP [78, 79]. It is characterized by a large number of neutrophils infiltrating the lining …
Hepatobiliary manifestations of IgG4-related disease
WebMay 25, 2010 · Type 1 AIP usually has the histologic features described above. Although the 2 groups have some histologic overlap, type 2 AIP is characterized by granulocytic epithelial lesions, which show neutrophils in the duct epithelium or duct epithelial damage in the lumen (or both) (Figure 1C) . It is still unclear whether the 2 subgroups represent ... WebAug 1, 2015 · Recently, cholangitis with granulocytic epithelial lesion was described in the literature. This entity is identified in 2 % of patients with sclerosing cholangitis. Patients are more likely children or young adults and often have an associated inflammatory bowel disease or rarely a pancreatitis. It is defined by the presence of neutrophilic ... the pendant double bonds
I. Definite diagnosis II. Probable diagnosis III. Possible diagnosis
WebOct 1, 2012 · Median time of follow up was 3.9 years (range 2.6–10.1). 4 patients had pancreatic biopsies with 2 of these patients showing granulocytic epithelial lesions (GELs). 4 patients received steroids ... WebAug 14, 2012 · Liver biopsy specimen revealed features of both autoimmune hepatitis and sclerosing cholangitis, the latter characterized by acute, hyperplastic and destructive … WebTermed "granulocytic epithelial lesions" (GEL) Lobules variably involved Predominantly lymphocytes and plasma cells but may include neutrophils May form neutrophilic abcesses; Moderate fibrosis centered on ducts. Less prominent than in lymphoplasmacytic sclerosing pancreatitis; No obliterative venulitis or arteritis the pendant