Irf4 and b cell
WebJP7239597B2 JP2024545734A JP2024545734A JP7239597B2 JP 7239597 B2 JP7239597 B2 JP 7239597B2 JP 2024545734 A JP2024545734 A JP 2024545734A JP 2024545734 A JP2024545734 ... WebJan 19, 2024 · IRF4 regulates the immunosuppressive function of Tregs in primary immune thrombocytopenia [ 19 ]. IRF4 participates in the regulation of immune response and the development metabolism of immune cells [ 20 ]. More importantly, IRF4, as an upstream transcription factor of BCL6, negatively regulates the expression of BCL6 [ 21 ].
Irf4 and b cell
Did you know?
WebIRF4 is a gene located on chromosome 6 that encodes for the IRF4 protein belonging to the IRF family of transcription factors. Large B-cell lymphoma with IRF4 rearrangement … WebDec 2, 2024 · B cells, or B lymphocytes, are an important and complex cell type that plays central roles in humoral immunity against infections, autoimmunity and transplantation. ... CD24– as well as by the expression of transcription factors BLIMP1, XBP1, and IRF4. In addition, plasma cells express high levels of CD138 (SDC1). ...
WebOnce a B cell is within the quiescent mature follicular (FO) or marginal zone (MZ) pools, these transcriptional programs are maintained at steady state unless activating signals are received. 2. Activation initiates transcriptional program shifts WebDec 10, 2024 · In B cell population, IRF4 has a biphasic function acting both during early B cell development and in mature B cells during germinal center reaction after antigen …
WebApr 4, 2024 · IRF4 is highly expressed in B cells and plasma cells where it plays essential roles in controlling B cell to plasma cell differentiation and immunoglobulin class switching. Overexpression of IRF4 is found in MM patients' derived cells, often as a result of activating mutations or translocations, where it is required for their survival. WebDec 1, 2015 · IRF4 is an unusual component of the activated B cell gene-regulatory network, as it is an obligate controller of opposing cellular states and has been proposed to do this in a...
WebAug 10, 2024 · To explore the role of IRF4 in orchestrating B-cell differentiation trajectories in more detail, we adoptively transferred CTV-labeled Cd19 Cre/+ Irf4 fl/fl (IRF4 –/–) B …
WebApr 10, 2024 · Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA-sequencing, and ... bitimec speedy wash priceWebDec 24, 2024 · 9 likes, 0 comments - Izzat Daouk (@izzatdaouk) on Instagram on December 24, 2024: "Petite Maison Peeling Gel gently cleanses the dead skin cells on the skin and makes the skin look..." Izzat Daouk on Instagram: "Petite Maison Peeling Gel gently cleanses the dead skin cells on the skin and makes the skin look much brighter. bitim outWebFeb 14, 2014 · The interferon regulatory factor 4 (IRF4) is an important immunological transcription factor required for B-cell maturation 3 and for the maintenance of various CD4 + T-cell subsets... bitimrewWebMar 19, 2024 · To determine the transcriptional targets controlled by IRF4, we next performed ChIP-seq analysis in TL-Om1 cells. Given that both IRF4 and NF-κB are aberrantly activated in ATL cells, we hypothesized that IRF4 may cooperate with NF-κB in ATL cells, and hence performed ChIP-seq analysis for p65, one of the major subunits of NF-κB, in the … data analytics for accounting 3rd edition pdfWebJan 1, 2015 · Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). The interferon regulatory factor 4 (IRF4) is known to be highly expressed in both ALK + and ALK − ALCLs. However, the role of IRF4 in the … data analytics for accounting solution manualWebDownload scientific diagram Expression of IRF8, IRF4, and PU.1 during late B cell differentiation. (A) Resting lymph node B cells from Prdm1 gfp/+ mice from publication: The transcription ... biti motors culcairn used carsWebOct 5, 2024 · To do this IRF4-, BACH2-, and IRF4/BCL6 dou- ble-deficient DT40 B cell lines were generated. In this thesis, I demonstrate a new role for IRF4 as a regulator of BCR … bitimply crypto