Proctive role of mg53
Webb27 aug. 2024 · Background . The heart is one of the most commonly affected organs during sepsis. Mitsugumin-53 (MG53) has attracted attention in research due to its cardioprotective function. However, the role of MG53 in sepsis-induced myocardial dysfunction (SIMD) remains unknown. The purpose of this study was to explore the … Webb6 nov. 2024 · The role of MG53 in the plasma membrane was one of the first discovered physiological functions of the protein. It is now well established that MG53 facilitates vesicle translocation to the plasma membrane where it leads to repair following injury ( Figure 1C; Cai et al., 2009a ).
Proctive role of mg53
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Webbresistance and MetS. The important role of MG53 in skeletal muscle insulin resistance has been independently confirmed by another group (Yi et al., 2013). Also, a recent report … WebbThe MG53 (also known as TRIM72) is a conserved, muscle-specific tripartite motif family protein that is abundantly expressed in cardiac or skeletal muscle and present in circulation. Recently, the MG53 had been hypothesized to serve a dual role in the heart: involving in repairing cell membranes tha …
Webb28 nov. 2024 · For instance, short-term intensive exercise increases serum MG53 levels in the mdx dystrophic mice (but not in the wt mice) as a result of muscle injury and subsequent leakage of MG53. 21 Nevertheless, understanding the potential role of MG53 in physiological regulation of insulin sensitivity by physical activity and nutrients requires …
Webb30 apr. 2024 · Mechanistically, MG53 regulates NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity and subsequently controls KChIP2 transcription. Chromatin immunoprecipitation demonstrates NF … WebbFirst, MG53 participates in plasma membrane repair of the heart, skeletal muscle, and, other tissues. Second, MG53 is essentially involved in the cardioprotection of cardiac …
Webb15 jan. 2024 · However, the biological function and mechanisms of MG53 in the TGF-β1 signaling pathway and cardiac fibrosis remain elusive. In the present study, we researched on human atrial tissue and rat atrial fibroblasts to investigate the relationship between MG53 and the TGF-β1 signaling pathway, and the role of MG53 in atrial fibrosis and AF.
Webb20 juli 2024 · Since we have demonstrated that MG53 exerted the anti-tumor effect by inhibiting RAC1-MAPK pathway, thus we further try to clarify whether MG53 could play a role in the response to sorafenib ... temba bavuma sa20Webb7 nov. 2024 · MG53 has been proven to be involved in repairing cell membrane damage. It has a protective effect on I/R injury in multiple oxygen-dependent organs, such as the heart, brain, lung, kidney, and liver. Recombinant human MG53 also plays a unique role in I/R, … temba bavuma newsWebb26 feb. 2024 · Mechanistically, in addition to MG53-induced dysregulation of IR and IRS-1, it also blocks insulin signaling by upregulating peroxisome proliferator-activated receptor … temba bavuma cricket saWebb11 okt. 2024 · MG53 is a muscle-specific TRIM-family protein that presides over the cell membrane repair response. Here, we show that MG53 present in blood circulation acts … temba bevumaWebb14 sep. 2024 · Loss of MG53 promotes lung tumorigenesis in mg53-/-mice. Studying mg53-/-mice, we noticed an interesting phenomenon: mg53-/-mice often develop lung tumors as they age. As shown in Fig. 1A, histological staining revealed localized areas in the mg53-/-lung sections with aggressive tumor proliferation, which were positive for … temba bavuma twitterWebbRecently, the MG53 had been hypothesized to serve a dual role in the heart: involving in repairing cell membranes that protect myocardial function while acting as an E3 ligase … temba bavuma test runsWebbThe MG53 (also known as TRIM72) is a conserved, muscle-specific tripartite motif family protein that is abundantly expressed in cardiac or skeletal muscle and present in … temba board